Spectacular antibody results after booster shots

Discussion in 'Coronavirus Pandemic Discussions' started by CenterField, Nov 22, 2021.

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  1. CenterField

    CenterField Well-Known Member Past Donor

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    Warning: small study and only with healthy subjects, and the idea that protection will last longer is speculative. Still, very interesting; particularly, the fact that with a booster, people who had Covid-19 before got 50 times more antibodies than after their infections.

    Protection against COVID-19 from an mRNA vaccine - either the Moderna or Pfizer/BioNTech shots - may last longer after the booster dose than after the original two-shot regimen, researchers speculated based on the results of a small new study. They measured vaccine responses before and after the boosters in 33 healthy middle-aged adults who had received their second doses an average of nine months earlier.

    Before the boosters, their antibody levels had decreased about 10-fold from levels early after their second dose. By 6 to 10 days after the booster, their antibody levels had climbed 25-fold and were five times higher than after two doses of the vaccine, according to a report posted on Sunday on medRxiv ahead of peer review.

    https://www.medrxiv.org/content/10.1101/2021.11.19.21266555v1

    In the volunteers who had COVID-19 before being vaccinated, antibody levels after the booster were 50-fold higher than after their infections.

    "Because these antibody levels are so robust, the booster could potentially give us protection for a longer duration than what we saw for two doses of the vaccine," study coauthor Alexis Demonbreun of Northwestern University Feinberg School of Medicine in Chicago, said in a statement.

    This is certainly encouraging, although of course one would want to see a larger study that also included older and sicker subjects.
     
  2. kreo

    kreo Well-Known Member

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    another B.S. from pharma used car salesmen
    small study = garbage
     
    Last edited: Nov 22, 2021
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  3. AmericanNationalist

    AmericanNationalist Well-Known Member

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    To be fair, OP notes right on the jump that it's a small study, but other larger studies have previously suggested that someone affected with COVID-19 would have a stronger immune response after the infection. I think the devil of the details isn't it becoming stronger, but how long specifically it would last.
     
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  4. kreo

    kreo Well-Known Member

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    There is no point to even mention small study other then sale pitch.
    The whole COVID propaganda is based on small studies, but when we look at the bigger picture we can see that COVID case trends stay intact regardless of vaccination.
     
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  5. CenterField

    CenterField Well-Known Member Past Donor

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    What other large studies? Much the opposite, there was one quite flawed study suggesting that, and several others including a very large and recent one in Kentucky involving thousands of patients, suggesting that vaccine immunity is better than infection-derived immunity. You need to update your notions.
     

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