Why the Zinc/Chloroquine treatment has been effective: Scientific evidence.

Here, what everyone wanted: No Orange Man Bad. You don't see him, you don't hear him, nada. You wanted scientific evidence on why it would be effective. No one said, cure, no one said miracle cure or any of the fake talking points. It was said to potentially be effective.

This video demonstrates why it might be effective.

 

That is an entirely different usage of cloroquine. In fighting Malaria, the cloro makes the cell toxic to the protozoa.

This usage makes the cell permeable, or attractive to the zinc. Allowing the zinc to mix in cell.The Zinc is the toxin to the virus, if true. The cloroquine being only a catalyst.

This makes some sense, as zinc has an effect on the common cold CORONAVIRUS.

Cloroquine has been said to have a SMALL effect, but MAYBE it is enlarged, by using in combination with the zinc. We do not know if there are other things as good or better, at allowing the zinc in the cell, or if cloro is unique in this regard.

 

Exactly, well done....

 

I'm reminded of this exchange between Andy Sipowitz (Dennis Franz) and his partner Bobby Simone (Jimmy Smits) on NYD Blue.

Sipowitz- "What do you think of zinc?"
Simone- "You mean like in your diet?"
Sipowitz-"No. I mean as in a mining venture!"

 

Nobody said it is a miracle cure? Have you followed the forum? There was even a thread with "100% effective" in the title.

On the other hand, nobody on the other side actually said that it didn't work. They said that it COULD work, but that is is unproven and could also potentially be harmful. Also, it is no substitute for social distancing.

Now, going back to the science. There is no question that chloroquine is a cation ionophore. There is also no question that zinc inhibits enzymes, such as the virus polymerase.

The paper that is referred to in the video, however, shows that chloroquine, at most, doubles the effect of zinc alone. That's not a large effect. Second, it only does so at very high zinc concentrations. For reference, zinc kills neurons at concentrations that were used in this study, i.e. 500 microM.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872358/

This is an interesting article. It goes into the details of zinc physiological action, which is highly complex. It is an intrinsic component that our body needs, for many physiological functions, including neurotransmission. ZInc binds to the protein I work with in my lab. That's why I once had a project studying zinc's function. It also binds to 1000s of other targets, to many at lower concentration than what is needed for the ionophore effect. The video you posted is good, but it rather oversimplifies the mechanism of zinc action. Its covid effect is a hypothesis at this point, far from being proven.

 

Of the explanations that I've heard this is the one that seems to make most sense. I saw one video where the researcher said that even though the effect is seen in the petri dish, it doesn't always translate to use in humans. That there have been studies on other viruses where they could efficiently stop them in a lab, using the techniques described here, but could not stop the virus in a live subject.

 

A YouTube presentation

Yes VERY scientific

NOT!!!

Although it actually does quote papers ( and I would have to do a google scholar search to verify the papers) but this is still an in vitro study NOT in vivo

The are a god awful amount of drugs that work in the lab but are worse than useless in real life. Why I am skeptics about HCQ is that it has been trialled for use in other viral infections like HIV but has not lived up to the promise

 

Nobody has questioned that it might be effective. What has been questioned are the claims that it is. Despite there not being supporting scientific evidence.

Chlorquine is one of four treatments that were deemed "promising" by the W.H.O. as part of a program called SOLIDARITY.

https://www.sciencemag.org/news/202...l-four-most-promising-coronavirus-treatments#

But here's the main problem... If this drug turned out to be effective, Trump's insistence on people "trying" this drug has enormously increased its use "just in case". And scientists fear that this could create a mutation of the coronavirus that is immune to this treatment. Rendering the treatment ineffective.

 

That's one of the major issue with life science research. One can't count the number of studies that showed promising results in the test tube, or even in animal studies, but were totally worthless in humans.

 

FALSE HOPE: Doctors, pols urge earlier use of ‘miracle’ coronavirus drug cocktail.

“Last week, the American Society of Thoracic Surgeons issued guidelines for doctors to use the anti-malarial if they are in the advanced stages of the coronavirus, but some physicians say that it needs to be administered long before that.”​

Trump Miracle Pills Could Be a Real Game Changer

 

You got it.

 

What is needed is a John Galt in infectious disease in medicine. Wonder if he’ll show.